Welcome to
OACS Ireland

Organisation Anticonvulsant Syndromes Ireland
Charity Number (RCN) 20204646

OACS - Who Are We?

OACS Ireland was a voluntary group that was set up in 2017. OACS Ireland have now received Charity Status, we provide support, help, and advice to other families, whose children have been affected by Foetal Anti-Convulsant Syndrome (F.A.C.S) in Ireland.

Our Mission

The Purpose of OACS Ireland is to ensure that people living with FACS and their families will experience better recognition, improved public health services, and support.

How We Can Help

We are here to support all families impacted by Foetal Anti-Convulsant Syndromes (FACS). Foetal Anti-Convulsant Syndrome is caused when the anti-convulsant medicine a woman takes during pregnancy affects the foetus.

FVS - Foetal Valproate Syndrome is a range of devastating birth defects that can occur from the side effects of taking an anti-epilepsy or other drugs which contain valproic acid (VPA) during pregnancy. Despite studies dating back to the 1980’s, both industry and national governments across the world (including Ireland), were slow to act on overwhelming evidence of the side effects of such drugs, including Epilim. Progress on addressing this issue is thanks to the advocacy of one Irish parent, Karen Keeley. Thanks to Karen and the patient advocacy group she founded, the Organisation for Anticonvulsant Syndrome (OACS) Ireland, combined with a European Medicines Agency judgement in February 2018, there are now considerably heightened warnings about the dangers of FVS.

Epilim - (Valproate) -Edition of the HPRA Drug Safety Newsletter

Important: Please do NOT STOP taking your medication without speaking to your Health Care Professional.

Our Core Values


We take responsibility for using our resources efficiently, achieving measurable results, and being accountable to supporters, partners and, most of all, children.


To enhance the capacities of its members through information, exchange, networking, mutual support, and potentially joint actions.


To represent its members and people living with a Foetal Anticonvulsant Syndrome at large, throughout Ireland.


We are open to new ideas, embrace change, and take disciplined risks to develop sustainable solutions for the organisation.

What is F.A.C.S?

Foetal Anti-Convulsant Syndrome is caused when a mother uses anti-convulsant medication during pregnancy. (also known as Anti-Epileptic Drugs, or AEDs.)  AEDs are not only used to treat epilepsy but are also used to treat pain, migraine, bipolar, mental health and other conditions.

One of the challenges that can occur for the pregnant mother with epilepsy is that some mothers tend to have more severe seizures during pregnancy.  As a result of this, some doctors will up the dosage during the pregnancy which can make the foetus more susceptible to problems during pregnancy.

The risk of disability varies according to the specific drug taken; however, there are some patterns to be seen in all cases

The risk for any one drug is about 6 out of 100 (that is double the background level of risk). The risk increases with the number of drugs. This means that babies of women taking two or more AEDs have between 10-14 out of 100 risk of being born with a problem. For those taking the combination of valproate, carbamazepine and phenytoin, the risk can be as high as 50 out of 100.

There is also evidence that taking a larger dose of antiepileptic medication carries a greater risk for the baby. Babies of mothers taking more than 1 g per day of valproate have more than twice the risk of congenital malformations, compared with those exposed to 600 mg or less.

In relation to FVSD/ FVS is a rare condition that occurs when a baby is exposed to VPA (brand names include Epilim Depakene, Convulex, Depakote, Encorate, Valpakine, etc) during the first trimester VPA crosses the placenta and interferes with normal development causing developmental abnormalities in the fetus and malformations. Fetal valproate syndrome (FVS) may occur if a developing baby is exposed to valproic acid during pregnancy. Valproic acid, also known as valproate, is a medication that is often used to treat epilepsy, bipolar disorder, and migraines. Many babies who are exposed to this medication during pregnancy are born healthy with normal growth and development. However, studies have found that women who take valproate during pregnancy have a greater chance of having a baby with a major birth defect or other health problem. Symptoms of FVS vary but may include characteristic facial features, spina bifida, congenital heart defects, cleft lip and/or cleft palate, genital abnormalities, skeletal abnormalities, and developmental delay. A child exposed to valproic acid may be at a higher risk for learning and behavioral problems which include ADHD, Autism. Although there is no cure for FVS, FVSD and/or FACS, many of the possible signs and symptoms of FVS do have treatments or therapies available. Early intervention programs may also be helpful

Please remember there is NO SAFE dose-effect of Epilim (Valproate) in pregnancy!

Epilim (Sodium Valproate) has a history of adverse developmental effects. The drug is unusual in that its teratogenicity in humans was predicted from animal studies, without any knowledge of mechanism (Brown et al., 1980; Kao etal., 1981).

Valproic acid, first marketed in Europe in 1967, appeared to be without adversity to development over the initial 13 years following marketing. Then, in the early 1980s, Dalen’s and her associates made the initial association of VPA to birth defects (Dalen’s et al., 1980; Dalen’s, 1981). They reported an infant who died at 19 days of age, was growth retarded, and who had multiple malformations of the face and brain, heart, and skeleton, among other defects. The mother of the infant had taken 1000 mg/day of VPA throughout gestation. These observations were followed by several case reports and other publications attesting to the malformation effects of the drug when administered to a pregnant mother during gestation.

Some characteristics of foetal anticonvulsant syndrome involve the following areas: spina bifida; cleft lip and palate; facial and skull; limb defects; ear malformations; skeletal malformation; heart, kidney, urinary tracts, and sexual organ malformations, developmental delay, facial features, low muscle tone, Social Communication Disorder, Autism Spectrum Disorder, Attention deficit hyperactivity disorder (ADHD) Speech and Language, Growth and general health, Joint hypermobility, Genitourinary defects. OACS Ireland will provide a full list of FACS conditions to new our website shortly.

Want to know more about anti-convulsant
medication during pregnancy

News & Resources

The HPRA #MedSafetyWeek RE-COVID-19

By oacsireland | November 1, 2021

This year’s, annual #MedSafetyWeek the HPRA global social media campaign which stakeholders have been asked to support on social media throughout this week-long campaign from 1- 7 November 2021 is all about COVID-19 vaccines side effects (Adverse Drug Reactions). #MedSafetyWeek is…

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New Irish study finds that ‘continued effort is needed’ in reducing valproate risks.

By Karen | September 17, 2021

A new study which investigated the awareness, knowledge, and practice of healthcare professionals in implementing the Sodium Valproate (Epilim) Pregnancy Prevention Program (PPP) has been published in the medical journal Expert Opinion on Drug Safety. The study was conducted by researchers…

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OACS Ireland & Epilepsy Ireland urge the Minister to act on his promise for a fast & fair inquiry into the Historical use of Epilim (Sodium Valproate).

By wpengine | August 12, 2021

It has been 46 years since the granting of the license of Epilim (Sodium Valproate) in Ireland. The overwhelming impact it has had on families clearly evident. OACS Ireland families have been dealt a dreadful hand in life, and it…

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The HSE Chief Officer’s Community Operation List for Foetal Valproate Spectrum Disorder/Syndrome (FVSD) / (FVS).

By oacsireland | June 22, 2021

For families that have received a diagnosis of Foetal Valproate Spectrum Disorder/Syndrome (FVSD) / (FVS). The HSE estimate that 1,250 children in Ireland have been impacted by exposure to (Sodium Valproate) (Epilim) in the womb. Many of these families were…

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Sodium Valproate (Epilim) – Matters for your TD/Senator

By Karen | June 21, 2021

As you know, OACS Ireland alongside our colleagues in Epilepsy Ireland are continuing to keep the pressure on Government regarding the many outstanding matters surrounding Sodium Valproate (Epilim). The establishment of an inquiry into the historical licensing and prescribing of…

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“The Epilim (Sodium Valproate) Dublin Protest by parents & children impacted by the drug”

By Karen | June 2, 2021

OACS Ireland is a voluntary organisation that supports families who have been impacted by the drug Epilim (Sodium Valproate. Epilepsy Ireland is the national patient organisation supporting and representing people with epilepsy and their families. OACS Ireland and Epilepsy Ireland…

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